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Olfactory dysfunction and functional connectivity changes in cognitively normal Parkinson’s disease

In this study, we investigated brain atrophic changes and functional connectivity alterations in Parkinson’s disease patients with severe hyposmia, patients with no/mild hyposmia, and healthy controls. All patients were assessed using Odor Stick Identification Test for the Japanese (OSIT-J) and Addenbroke’s Cognitive Examination-Revised (ACE-R) for their odor-identification performance and general cognitive function, respectively. We used resting state functional magnetic resonance imaging to evaluate functional connectivity.


001 rest eyes closed


  • Gen Sobue
  • Masahisa Katsuno
  • Daisuke Mori
  • Satoshi Maesawa
  • Mizuki Ito
  • Tatsuya Hattori
  • Michihito Masuda
  • Yasutaka Kato
  • Rei Ogura
  • Kazunori Imai
  • Reiko Ohdake
  • Yasuhiro Tanaka
  • Takashi Tsuboi
  • Kazuhiro Hara
  • Epifanio Bagarinao
  • Kazuya Kawabata
  • Hirohisa Watanabe
  • Noritaka Yoneyama

Contact Information:

Name: Epifanio Bagarinao

Acknowledgements and Funding:

This research was supported in part by the following: a Grant-in-Aid from the Research Committee of Central Nervous System Degenerative Diseases by the Ministry of Health, Labour, and Welfare, Integrated Research on Neuropsychiatric Disorders project, carried out by SRBPS; a Grant-in-Aid for Scientific Research on Innovative Areas (Brain Protein Aging and Dementia Control 26117002) from the MEXT of Japan; Integrated Research on Neuropsychiatric Disorders carried out under the Strategic Research Program for Brain Sciences, Scientific Research on Innovative Areas (Comprehensive Brain Science Network); and Integrated Research on Depression, Dementia, and Development Disorders by the Strategic Research Program for Brain Sciences from the Japan Agency for Medical Research and Development (AMED).

External Publication Links:

Severe hyposmia and aberrant functional connectivity in cognitively normal Parkinson’s disease

Sample Size:


Scanner Type:

Siemens Magnetom Verio 3T scanner



Accession Number:


How to cite this dataset:

In addition to any citation requirements in the dataset summary please use the following to cite this dataset:

This data was obtained from the OpenfMRI database. Its accession number is ds000245



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Revision: 1.0.0 Date Set: Oct. 27, 2017, 9:56 p.m.


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