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DWI Traveling Human Phantom Study

A number of studies are now collecting diffusion tensor imaging (DTI) data across sites. While the reliability of anatomical images has been established by a number of groups, the reliability of DTI data has not been studied as extensively. In this study, five healthy controls were recruited and imaged at eight imaging centers. Repeated measures were obtained across two imaging protocols allowing intra-subject and inter-site variability to be assessed. Regional measures within white matter were obtained for standard rotationally invariant measures: fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity. Intra-subject coefficient of variation (CV) was typically <1% for all scalars and regions. Inter-site CV increased to *1%–3%. Inter-vendor variation was similar to inter-site variability. This variability includes differences in the actual implementation of the sequence.


  • Laura A. Flashma
  • Elizabeth Aylward
  • Mark J. Lowe
  • Sarah Reading
  • Jessica A. Turner
  • Karl G. Helmer
  • Susumu Mori
  • Kelvin Lim
  • Bryon A. Mueller
  • Bradley D. Bolster Jr.
  • Jeffrey D. Long
  • Hans J. Johnson
  • Dawei Liu
  • Joy T. Matsui
  • Vincent A. Magnotta

Contact Information:

Name: Hans J. Johnson

Acknowledgements and Funding:

This work was supported, in part, by awards from CHDI Foundation, Inc.; NIH R01NS050568; NINDS NS40068 Neurobiological Predictors of Huntington’s Disease; and NINDS R01 NS054893 Cognitive and Functional Brain Changes in Preclinical HD. Dr. Turner was supported by NCRR 1 U24 RR021992 from the Functional Imaging Biomedical Informatics Network (S.G. Potkin, PI) for her work on this project while at the University of California, Irvine. This publication was supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant UL1RR024979. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

External Publication Links:

Multicenter reliability of diffusion tensor imaging.

Sample Size:


Scanner Type:

Siemens 3T TIM Trio, Philips 3T Achieva



Accession Number:


How to cite this dataset:

In addition to any citation requirements in the dataset summary please use the following to cite this dataset:

This data was obtained from the OpenfMRI database. Its accession number is ds000206



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Revision: 1.0.0 Date Set: Sept. 1, 2016, 9:44 p.m.


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